Диагностика и лечение сепсиса и септического шока

Рефераты к статьям, вышедшим в Japan Journal of Critical Care for Endotoxemia за 2001-2006 годы

Отчёты о преведённых и ведущихся клинических испытаниях "Тораймиксина" и "ЕАА" на сайте ClinicalTrials.gov (обновляется)

Endotoxaemia in paediatric critical illness - a pilot study
Shamik Dholakia, David Inwald, Helen Betts, Simon Nadel.
Critical Care 2011, 15:R141 doi:10.1186/cc10264
Key messages: Children with critical illness of any cause are likely to have endotoxaemia. Endotoxaemia can be accurately detected by a simple bedside test. Endotoxaemia may be associated with increased severity of illness and length of stay in PICU. It is likely that the source of endotoxin in these children is from their own gut or lung. If the findings of this study are confirmed in larger studies, anti-endotoxin therapies may be a logical adjunct to treatment of paediatric critical illness.

Cost-Effectiveness Analysis of Polymyxin-B Immobilized Fiber Column and Conventional Medical Therapy in the Management of Abdominal Septic Shock in Italy
Patrizia Bertoa, Claudio Roncob, Dinna Cruzb, Rita Maria, Melottic Massimo Antonelli.
Blood Purif 2011;32:331–340
Key Words: Apache score, Blood, Cost-effectiveness analysis, Critical care, Economics, Endotoxins, Hemoperfusion, Hospital mortality, Intensive care units, Polymyxin, Polymyxin B, Septic shock

Hemoperfusión con polimixina B en shock séptico secundario a abscesos hepáticos por Klebsiella pneumoniae. (Hemoperfusion with polymyxin B in septic shock secondary to Klebsiella pneumoniae induced liver abscesses);
M Cerezo-Arias, G Borge-Rodríguez, I Cerezo-Arias, M Benítez-Morillo; Servicio de Medicina Intensiva, Hospital de Mérida, Mérida, Badajoz, España.;
Medicina Intensiva 10/2011; DOI: 10.1016/j.medin.2011.08.003
Key words: Humans, Female, Middle Aged, Hemoperfusion/methods, Polymyxin B/therapeutic use, Shock, Septic/drug therapy, Klebsiella Infections/drug therapy, Liver Abscess/complications, Klebsiella pneumoniae

A Case of Successful Treatment with Polymyxin B-immobilized Fiber Column Direct Hemoperfusion in Acute Respiratory Distress Syndrome after Influenza A Infection;
Kazuhiro Yatera, Kei Yamasaki, Toshinori Kawanami, Susumu Tokuyama, Takayuki Ogoshi, Minako Kouzaki, Shuya Nagata, Chinatsu Nishida, Chiharu Yoshii and Hiroshi Mukae;
Internal Medicine 50: 601-605, 2011; DOI: 10.2169/internalmedicine.50.4604;
Key words: acute respiratory distress syndrome, influenza A, polymixin B-immobilized fiber, acute lung in- jury, PMX-DHP

Effective use of polymyxin B hemoperfusion in septic shock complicated by urosepsis
P.Malleshappa, R.Ranganath, A.P.Chaudhari, P.Singhai, M. Aghariya, A.B.Shah
Department of Nephrology, Lilavati Hospital and Research Centre, Mumbai, India.
Indian J Nephrol. 2011 Jan ;21 (1):41-3 21655169
Key words: hemoperfusion; septic shock; urosepsy; polymyxin; shock; septic; shock complicate; direct hemoperfusion; effective use; complicate; b-immobilized; polymyxin-b; therapy; effective; shock within;

Endotoxemia related to cardiopulmonary bypass is associated with increased risk of infection after cardiac surgery: a prospective observational study
David J Klein 1*, Francoise Briet 2, Rosane Nisenbaum 3, Alexander D Romasch in 4 and C David Mazer 5
Critical Care 2011, 15:R69 doi:10.1186/cc10051
Key messages: The prevalence of high levels of endotoxemia (as measured by the Endotoxin Activity Assay) in patients undergoing elective cardiopulmonary bypass supported aortocoronary bypass grafting surgery is uncommon compared to previous reports. Endotoxemia correlates with the duration of surgery. Patients who do have cardiopulmonary bypass associated endotoxemia are at a significantly increased eight-fold risk of developing post-operative infections.

Polymyxin B hemoperfusion in sepsis: perseverance is the key.
Taccone P.
Minerva Anestesiol. 2010 Jun;76(6):387-8. Epub 2010 Apr 12.

Effects of hemoperfusion with an immobilized polymyxin-B fiber column on cytokine plasma levels in patients with abdominal sepsis.
Zagli G1, Bonizzoli M, Spina R, Cianchi G, Pasquini A, Anichini V, Matano S, Tarantini F, Di Filippo A, Maggi E, Peris A.
Minerva Anestesiol. 2010 Jun;76(6):405-12. Epub 2010 Apr 12.
Key words: Sepsis - Polymyxin-B fiber column - Cytokines - Hemoperfusion.

Endotoxin elimination in sepsis: physiology and therapeutic application
Klaus Buttenschoen, Peter Radermacher, Hendrik Bracht
Langenbecks Arch Surg (2010) 395:597–605
Keywords: Lipopolysaccharide, Elimination, Detoxification, Degradation, Adsorber

Effectiveness of Endotoxin Scattering Photometry for Determining the Efficacy of Polymyxin B-immobilized Fiber Treatment in Septic Shock: Report of a Case
Yuichiro Sakamoto1, Kunihiro Mashiko1, Toru Obata and Hiroyuki Yokota
J Nippon Med Sch 2010; 77 (2)
Key words: polymyxin B -immobilized fiber (PMX), septic shock, endotoxin scattering photometry

Polymyxin B-immobilized Fiber Column Hemoperfusion Treatment for Drug-Induced Severe Respiratory Failure: Report of Three Cases
Toshiki Yokoyama, Kenji Tsushima, Hiroshi Yamamoto, Michiko Ito, Toshihiko Agatsuma, Tomonobu Kozumi and Keishi Kubo
Inter Med 49: 59-64, 2010
Key words: interstitial lung disease, polymyxin B-immobilized fiber column treatment, drug-induced lung disease, Krebs von den Lungen-6 (KL-6)